Objective:

To compare the effectiveness of oral acetazolamide 250 mg, topical brinzolamide 1% and dorzolamide 2% on intraocular pressure (IOP) during the early period after phacoemulsification surgery.

Material and Methods:

The study was planned prospectively in our clinic under the same technique and operation conditions, applying uncomplicated phacoemulsification surgery in 80 eyes of 68 patients without another pathology. When 38 patients were men, 30 patients were women. Patients were randomly divided in four groups without thinking their right or left eyes, age, and sex. It was applied dorzolamide 2% for first group, brinzolamide 1% for second group, oral asetazolamide 250 mg for third group after operation immediately, then in 12th hour and 24th hour. It was not applied treatment for fourth group that was controlling group. IOP of patients were measured using Goldmann applanation tonometer preoperatively and 4th hour and 24th hour postoperatively.

Results:

When before and after surgery 4th hour and 24th hour IOP measurement values compared, group 1 and 2 was found no significantly different (p>0.05), but group 3 and 4 were significant statistically ( p<0.001 ve p<0.05). IOP values that were measured before and after surgery in 4th and 24th. hour were statistically compared. When Group 1 and 3, Group 2 and 3 compared before and after surgery in 24th hour IOP average were not significant statistically (p>0.05), but they were significant statistically postoperative 4th hour (p<0.05). When Group 1 and 2, Group 1 and 4, Group 2 and 4, Group 3 and 4 compared before and after surgery in 4th and 24th hour, it was not observed significant statistically as IOP average (p>0.05).

Conclusion:

When topical brinzolamide and dorzolamide was more effective than acetazolamide IOP control 4 hours after phacoemulsification, it was found similar effects at 24 hours. Topical carbonic anhydrase inhibitors were preferred especially for patients that had sistemical illnesses and risky oral asetazolamide treatment.

Keywords: Electroencephalography, epilepsy, epileptiform abnormalities