Link Between Pregnancy Outcomes and Anticardiolipin Antibody in Subjects with Abortus İmminens


  • Yasemin Alan
  • Murat Alan
  • Beril Gürlek
  • Yüksel Kurban
  • İbrahim Uyar
  • Yaşam Kemal Akpak
  • Ahmet Nuri Danışman

Received Date: 06.03.2018 Accepted Date: 05.08.2018 Med J Bakirkoy 2019;15(2):136-141


Abortus imminens is a critical complication observed 10-20% of all pregnant women. Subchorionic hematoma is an important parameter in the diagnosis of abortus imminens; however, it is yet to be known the exact cause of subchorionic hematoma. A relation is thought to exist between anti-cardiolipin antibodies and subchorionic hematoma. So, we hereby in this study have compared the positiveness of the anti-cardiolipin antibodies in women with and without subchorionic hematoma. We have as well examined whether there is a relation between pregnancy outcomes and anti-cardiolipin positiveness.


The study has been planned as a case-controlled one, in which 41 women with abortus imminens and subchorionic hematoma; and 29 women with abortus imminens and without subchorionic hematoma were included and where the demographic data of those women were defined. The level of anti-cardiolipin antibodies (IgG, IgM) was measured by ELISA method.


No substantive difference has been detected between women with abortus imminens having subchorionic hematoma; and women with abortus imminens not having subchorionic hematoma in terms of age, parity and gravity. Compared to the women without subchorionic hematoma, the anti-cardiolipin antibody positiveness has been observed to be higher in the women with subchorionic hematoma in statistical terms. Furthermore, unfavorable pregnancy outcomes have been seen at a higher rate in pregnant women with positive anti-cardiolipin antibody compared to the nonpositive ones in the study.


The circulating anti-cardiolipin antibody levels were found to be elevated in women with abortus imminens having subchorionic hematoma compared to those women with abortus imminens not having subchorionic hematoma and there was a relationship between anti-cardiolipin antibody and unfavorable pregnancy outcome.

Keywords: Abortus imminens, subchorionic hematoma, anti-cardiolipin antibody, pregnancy outcomes

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