Objective:
Acute renal failure associated with obstructive jaundice is still a major clinical problem, and has yet not been completely understood. Many studies showed that one of the most important features of the process was endotoxemia and subsequent sepsis. We investigated the effects of ursodeoxycholic acid and piperacillin-tazobactam on acute renal failure associated with obstructive jaundice.
Material and Methods:
Forty male Spraque-Dawley rats were divided into four equal groups. First group was considered to be control group, and had only sham laparotomy. Obstructive jaundice models were created by ligation of the common bile duct in other three groups. Second group had no treatment; third group had enteral ursodeoxycholic acid treatment; fourth group had parenteral piperacillintazobactam treatment. Tissue and blood samples were obtained for the assessment of biochemical and histopathological parameters.
Results:
Endotoxin levels of treatment groups were significantly lower than the jaundiced group without treatment, but were significantly higher than control group. Histopathological examination revealed obvious renal tubular necrosis in all groups but in control group.
Conclusion:
Neither ursodeoxycholic acid nor piperacillin-tazobactam has a statistically significant impact on development of acute renal failure associated with obstructive jaundice.
Keywords: Obstructive jaundice, renal failure, endotoxemia, ursodeoxycholic acid, piperacillin-tazobactam