ABSTRACT

Toxic epidermal necrolysis is characterized by a blistering and peeling of the top layer of skin. Toxic epidermal necrolysis represents the most severe variant of a disease spectrum that consists of bullous erythema multiforme (EM) and Stevens-Johnson syndrome (SJS). This disorder can be caused by a drug reaction most often penicillin, anticonvulsants, nonsteroid antiinflamatory drugs or another disease such as viral, bacterial and mycoplasma pneumonia infections. The annual incidence of the disease is 0.4-1.2: 1 000 000. Boys are affected one a half times than girls. In this report 7.5 months old boy admitted to the hospital with the complaints of high fever, cough, malaise, poor sucking, three-four days exist cutaneous eruptions, and diarrhea with a history of co-trimoxasole treatment diagnosed as toxic epidermal necrolysis is presented.

Keywords: Toxic epidermal necrolysis, co-trimoxasole