ABSTRACT

Opioids are the most preferred agents in pain control. Their use may cause some dose dependent undesired effects. The administration of other anesthetic agents in combination with opioids may reduce the requirement for opioids. Our purpose is to evaluate the analgesic efficiency of metoclopramid administered in combination with pethidine.

In this double-blind study, the following random groups were formed with a total of 100 subjects. Control Group: no metoclopramid administered (n=25), Group M 0.25: 0.25 mg/kg metoclopramid administered at the end of the surgery (n=25), Group M 0.5: 0.5 mg/kg metoclopramid administered at the end of the surgery (n=25), Group M 0.5 extubation: 0.5 mg/kg metoclopramid administered after extubation (n=25).

We identified that the metoclopramid administered in elective gynecologic operations does not have any effect on the numeric rating scale values within the first 30 minutes following the extubation. Nevertheless, we observed that if a 0.5 mg/kg dose is administered immediately after the extubation, there is a significant decrease in the pethidine use within the first 24 hours after the 3rd hour.

Consequently, we can conclude that metoclopramid administered in elective gynecologic operations has a postoperative analgesic efficiency.

Keywords: Surgery, postoperative pain, metoclopramid