E-ISSN: 1305-9327 ISSN: 1305-9319
Platelet and Endothelial Cell Adhesion Molecule Expression in Pregnant Women with Preeclampsia
PDF
Cite
Share
Request
Research
VOLUME: 15 ISSUE: 3
P: 193-197
September 2019

Platelet and Endothelial Cell Adhesion Molecule Expression in Pregnant Women with Preeclampsia

Med J Bakirkoy 2019;15(3):193-197
DOI: 10.4274/BTDMJB.galenos.2018.20180326053945
Murat Alan 1
Beril Gürlek 2
Alpay Yılmaz 3
Neşe Lortlar 4
Ahmet Nuri Danışman 5
1. Tepecik Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, İzmir, Türkiye
2. Recep Tayyip Erdoğan Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Rize, Türkiye
3. Atatürk Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Onkoloji Kliniği, İzmir, Türkiye
4. Boston Üniversitesi Tıp Fakültesi, Biyomedikal Mühendislik Anabilim Dalı, Boston, Amerika Birleşik Devletleri
5. Acıbadem Hastanesi, Perinatoloji ve Yüksek Riskli Gebelikler Merkezi, Kadın Hastalıkları ve Doğum Kliniği, İstanbul, Türkiye
No information available.
No information available
Received Date: 26.03.2018
Accepted Date: 14.05.2018
Publish Date: 03.09.2019
PDF
Cite
Share
Request

ABSTRACT

Objective:

Despite the fact that preeclampsia (PE) is one of the most important health problems which affect pregnant women, the etiopathogenetic factors which lead to the illness are still yet to be known. Hereby in this study, we have aimed to investigate the expression levels of the platelet and endothelial cell adhesion molecule, PECAM-1, in the healthy placentas of preeclamptic and control group patients.

Methods:

The placental tissue samples have been obtained from the patients diagnosed with PE and from the postnatal placentas of the healthy pregnant women; and analyzed through immunohistochemical methods for the expression levels of the adhesion molecule, PECAM-1.

Results:

In the placentas of the control group, a weak involvement of PECAM-1 has been observed in the endothelial cells covering the vein walls of the placental villus; yet in the placentas of the PE group, the involvement level has been observed to be high.

Conclusion:

Due to the increase in the expression levels of PECAM-1 in preeclamptic placenta, the functional roles of these adhesion molecules are thought to be present in the pathophysiology of PE. And with this fact being known, decent treatment approaches will emerge in the future in order to avoid PE symptoms.

Keywords:
Preeclampsia, pregnancy, platelet endothelial cell adhesion molecule-1

References

1
Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet 2005;365:785-99.
2
Kim SY, Ryu HM, Yang JH, Kim MY, Ahn HK, Shin JS et al. Maternal serum and amniotic fluid inhibin A levels in women who subsequently develop severe preeclampsia. J Korean Med Sci 2004;19:688-92.
3
Tuzcu ZB, Asicioglu E, Sunbul M, Ozben B, Arikan H, Koc M. Circulating endothelial cell number and markers of endothelial dysfunction in previously preeclamptic women. Am J Obstet Gynecol 2015;213:533.
4
Gonzalez-Ouinter VH, Jimenez J, Wenche JY, Lucia M, Mauro BS, Lavrence BSH et al. Elevated plasma endothelial microparticles in preeclampsia. J. Obstet Gynecol 2003;189:589-93.
5
Krauss T, Kuhn W, Lakoma C, Augustin HG. Circulating endothelial cell adhesion molecules as diagnostic markers for the early identification of pregnant women at risk for development of preeclampsia. Am J Obstet Gynecol 1997;177:443-9.
6
Bürk MR, Troeger C, Brinkhaus R, Holzgreve W, Hahn S. Severely reduced presence of tissue macrophages in the basal plate of pre-eclamptic placentae. Placenta 2001;22:309-16
7
Konijnenberg A, van der Post JA, Mol BW, Schaap MC, Lazarov R, Bleker OP et al. Can flow cytometric detection of platelet activation early in pregnancy predict the occurrence of preeclampsia? A prospective study. Am J Obstet Gynecol 1997;177:434-42.
8
Zhou Y, Damsky CH, Fisher SJ. Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome? J Clin Invest 1997;1:2152-64.
9
Chaiworapongsa T, Romero R, Yoshimatsu J, Espinoza J, Kim YM, Park K et al. Soluble adhesion molecule profile in normal pregnancy and pre-eclampsia. J Matern Fetal Neonatal Med 2002;12:19-27.
10
Tziotis J, Malamitsi-Puchner A, Vlachos G, Creatsas G, Michalas S. Adhesion molecules expression in the placental bed of pregnancies with pre-eclampsia. BJOG 2002;109:197-201.
11
Lyall F, Greer IA, Boswell F, Young A, Macara LM, Jeffers MD. Expression of cell adhesion molecules in placentae from pregnancies complicated by pre-eclampsia and intrauterine growth retardation. Placenta 1995;16:579-87.
12
Wang X, Athayde N, Trudinger B. Endothelial cell expression of adhesion molecules is induced by fetal plasma from pregnancies with umbilical placental vascular disease. BJOG 2002;109:770-7.
13
Caluwaerts S, Vercruysse L, Luyten C, Pijnenborg R. Endovascular trophoblastinvasion and associated structural changes in uterine spiral arteries of the pregnant rat. Placenta 2005;26:574-84.
14
Geusens N, Hering L, Verlohren S, Luyten C, Drijkoningen K, Taube M. Changes in endovascular trophoblast invasion and spiral artery remodelling at term in a transgenic preeclamptic rat model. Placenta 2010;31:320-6.
15
Conrad KP, Vill M, McGuire PG, Dail WG, Davis AK. Expression of nitric oxide synthase by syncytiotrophoblast in human placental villi. FASEB J 1993;7:1296-76.
16
Furchgott RF, Vanhoutte PM. Endothelium-derived relaxing and contracting factors. FASEB J 1989;3:2007-18.
17
Petrozella L, Mahendroo M, Timmons B, Roberts S, McIntire D, Alexander JM. Endothelial microparticles and the antiangiogenic state in preeclampsia and the postpartum period. Am J Obstet Gynecol 2012;207:140.
18
Chen Q, Sousa JD, Snowise S, Chamley L, Stone P. Reduction in the severity of early onset severe preeclampsia during gestation may be associated with changes in endothelial cell activation: A pathological case report. Hypertens Pregnancy 2016;35:32-41.
19
Thakoordeen S, Moodley J, Naicker T. Serum levels of platelet endothelial cell adhesion molecule-1 (PECAM-1) and soluble vascular endothelial growth factor receptor (sVEGFR)-1 and -2 in HIV associated preeclampsia. Hypertens Pregnancy 2017;36:168-74.
20
Zeisler H, Livingston JC, Schatten C, Tempfer C, Knöfler M, Husslein P. Serum levels of adhesion molecules in women with pregnancy-induced hypertension. Wien Klin Wochenschr 2001;16:588-92.
21
Erol AY, Nazli M, Elis Yildiz S. Significance of platelet endothelial cell adhesion molecule-1 (PECAM-1) and intercellular adhesion molecule-1 (ICAM-1) expressions in preeclamptic placentae. Endocrine 2012;42:125-31.
22
Pijnenborg R, Anthony J, Davey DA, Rees A, Tiltman A, Vercruysse L. Placental bed spiral arteries in the hypertensive disorders of pregnancy. Br J Obstet Gynaecol 1991;98:648-55.