ABSTRACT

The aim of this study was to compare lead (Pb) and nickel (Ni) levels in tissue samples of benign meningiomas and glioblastoma multiformes.

This study was performed in pathologically diagnosed benign meningioma and glioblastoma multiforme specimens (20 specimens in each group and a total of 40 specimens) obtained from operations. Measurements of trace elements were performed with Shimadzu AA 680 atomic absorption spectrophotometer. p<0.05 was considered as statistically significant.

The level of lead in benign meningioma specimens was similar to that in glioblastoma multiforme specimens (p=0.817). The level of nickel in benign meningioma specimens were statistically higher than that in glioblastoma multiforme specimens (p=0.003).

The high Nickel content of benign meningiomas compared to that of glioblastoma multiformes and the possible correlation of nickel with meningioma formation should be further evaluated. We consider that our findings carry valuable data for new researches and can contribute to worthwhile information on pathogenesis of meningioma and glioblastoma multiforme.

Keywords: Glioblastoma multiforme, lead, meningioma, nickel