E-ISSN: 1305-9327 ISSN: 1305-9319
The levels of the d-dimer and all haemostatic factors in patients with and without deep venous thrombosis
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Researches
VOLUME: 6 ISSUE: 3
P: 113-116
September 2010

The levels of the d-dimer and all haemostatic factors in patients with and without deep venous thrombosis

Med J Bakirkoy 2010;6(3):113-116
Özgür Kemik 1
Aziz Sümer 1
Ahu Sarbay Kemik 2
Sevim Purisa 3
Sefa Tüzün 4
Çetin Kotan 1
1. Yüzüncü Yıl Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Van
2. İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Biyokimya Anabilim Dalı, İstanbul
3. İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Biyoistatistik Anabilim Dalı, İstanbul
4. Haseki Eğitim ve Araştırma Hastanesi, II. Cerrahi Kliniği, İstanbul
No information available.
No information available
Received Date: 03.06.2010
Accepted Date: 02.07.2010
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ABSTRACT

Conclusion:

In conclusion, we suggested that the plasma D-dimer and hemostatic factor levels may play an important role in diagnosis and treatment of deep venous thrombosis.

Results:

We obtained important results in patients with deep venous thrombosis compared to in patients without deep vein thrombosis. Age, BMI, aPTT, INR, and total cholesterol levels were not found statistically differences in patients with deep venous thrombosis (p>0,05). Plasma D-dimer, creatinin, factor VII:C, and Von Willebrand factor levels were found higher in patients with deep venous thrombosis than in patients without deep venous thrombosis (respectively, p<0,001, p<0,01). But, plasma fibrinogen levels were not found lower in patients with deep venous thrombosis (p<0,01).

Material and Methods:

We investigated the levels of the D-dimer and Von Willebrand factor by enzyme linked immunosorbent assay (ELISA) in 120 patients with deep venous thrombosis and in 115 patients without deep venous thrombosis. We used standard methods for detecting the levels of the cholesterol, creatinin, INR, factor VIII: C ratio, and aPTT. We used Clauss method for detecting the fibrinogen levels.

Objective:

Although improved diagnostic tools and treatment approach, deep venous thrombosis is still an important cause of morbidity and mortality. Deep venous thrombosis is a common condition that affects more than 250 000 patients each year in the United States. In spite of limitations of the available diagnostic tools for detecting deep venous thrombosis, laboratory tests such as plasma D-dimer has been gained much interest recently. So, we aimed to investigate the D-dimer and all hemostatic factors in patients with deep vein thrombosis.