E-ISSN: 1305-9327 ISSN: 1305-9319
The Role of Shear Wave Elastography in the Management of Breast Cancer Patients Receiving Neoadjuvant Chemotherapy Treatment
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Research
VOLUME: 14 ISSUE: 4
P: 437-442
December 2018

The Role of Shear Wave Elastography in the Management of Breast Cancer Patients Receiving Neoadjuvant Chemotherapy Treatment

Med J Bakirkoy 2018;14(4):437-442
DOI: 10.4274/BTDMJB.20181209113230
Safiye Tokgöz Özal
Ayşegül Akdoğan Gemici
Elif Hocaoğlu
Ercan İnci
1. İstanbul Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Radyoloji Anabilim Dalı, İstanbul, Türkiye
No information available.
No information available
Received Date: 09.12.2018
Accepted Date: 14.12.2018
Publish Date: 28.12.2018
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ABSTRACT

Objective:

The aim of this study was to evaluate the differences between shear wave elastography findings responders and non-responders in the follow-up of breast cancer patients receiving neoadjuvant chemotherapy (NAC).

Materials and Methods:

Between September 2015 and August 2018, 47 patients were evaluated retrospectively. The patients were measured by tru-cut biopsy before and after the diagnosis and at the end of the treatment with shear wave elastography (SWE). Measurements were taken from the hardest part of the mass and from the environment normal parenchyma. In addition, the ratio of the mass and parenchyma to each other (R) was recorded. Patients were followed up in the interim period.

Results:

The SWE value of the mass was higher in the patients who responded to NAC, whereas the SWE value decreased after the treatment (p=0.00). In patients without response, SWE values of the mass did not decrease significantly at the end of NAC. After the NAC, parenchymal SWE values were found to be increased in all patients. In patients without response, SWE values of the masses were significantly higher than those in patients with no response (p=0.029). When the values at the end of NAC treatment were examined, the patients with unresponsive response had higher SWE values than the patients with response (respectively; p=0.05, p=0.02).

Conclusion:

There is a statistically significant relationship between the response of NAC to breast tumors and the SWE values measured before and after treatment.

Keywords: Shear wave elastography, breast cancer, neoadjuvant chemotherapy, ultrasonography

References

1
Harbeck N, Gnant M. Breast cancer. Lancet 2017;389:1134-50.
2
Micog JS, van der Hage JA, van de Velde CJ. Preoperative chemoteraphy for woman with operable breast cancer. Cochrane Database Syst Rev 2007:CD005002.                                     
3
Houssami N, Macaskill P, von Minckwitz G, Marinovich ML, Mamounas E. Meta-analysis of the association of breast cancer subtype and pathologic complete response to neoadjuvant chemotherapy. Eur J Cancer 2012;48:3342-54.
4
Smith IC, Heys SD, Hutcheon AW, Miller ID, Payne S, Gilbert FJ, et al. Neoadjuvant chemotherapy in breast cancer: significantly enhanced response with docetaxel. J Clin Oncol 2002;20:1456-66.
5
Evans A, Whelehan P, Thomson K, Brauer K, Jordan L, Purdie C, et al. Differentiating benign from malignant solid breast masses: value of shear wave elastography according to lesion stiffness combined with gray scale ultrasound according to BI-RADS classification. Br J Cancer 2012;107:224–9.
6
Berg WA, Cosgrove DO, Doré CJ, Schäfer FK, Svensson WE, Hooley RJ, et al. Shear-wave elastography improves the specificity of breast US: The BE1 multinational study of 939 masses. Radiology 2012;262:435-49.
7
Berg WA, Mendelson EB, Cosgrove DO, Doré CJ, Gay J, Henry JP, et al. Quantitative maximum shear-wave stiffness of breast masses as a predictor of histopathologic severity. AJR Am J Roentgenol 2015;205:448–55.
8
King TA, Morrow M. Surgical issues in patients with breast cancer receiving neoadjuvant chemotherapy. Nat Rev Clin Oncol 2015;12:335–43.
9
Cho N, Im SA, Kang KW, Park IA, Song IC, Lee KH, et al. Early prediction of response to neoadjuvant chemotherapy in breast cancer patients: comparison of single-voxel (1)H-magnetic resonance spectroscopy and (18) Ffluorodeoxyglucose positron emission tomography. Eur Radiol 2016;26:2279-90.
10
Falou O, Sadeghi-Naini A, Prematilake S, Sofroni E, Papanicolau N, Iradji S, et al. Evaluation of neoadjuvant chemotherapy response in women with locally advanced breast cancer using ultrasound elastography. Transl Oncol 2013;6:17–24.
11
Jing H, Cheng W, Li ZY, Ying L, Wang QC, Wu T, et al. Early Evaluation of Relative Changes in Tumor Stiffness by Shear Wave Elastography Predicts the Response to Neoadjuvant Chemotherapy in Patients With Breast Cancer. J Ultrasound Med 2016;35:1619-27.
12
Hayashi M, Yamamoto Y, Ibusuki M, Fujiwara S, Yamamoto S, Tomita S, et al. Evaluation of tumor stiffness by elastography is predictive for pathologic complete response to neoadjuvant chemotherapy in patients with breast cancer. Ann Surg Oncol 2012;19:3042–9.
13
Evans A, Armstrong S, Whelehan P, Thomson K, Rauchhaus P, Purdie C, et al. Can shear-wave elastography predict response to neoadjuvant chemotherapy in women with invasive breast cancer? Br J Cancer 2013;109:2798-802.
14
Ma Y, Zhang S, Li J, Li J, Kang Y, Ren W. Comparison of strain and shear-wave ultrasonic elastography in predicting the pathological response to neoadjuvant chemotherapy in breast cancers. Eur Radiol 2017;27:2282-91.
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