ABSTRACT

Amoxicillin-clavulanic acid (ACA) related hepatotoxicity is among the most common causes of drug-related hepatotoxicity. Cholestatic liver injury is the most common type. Symptoms usually begin 1-4 weeks after ingestion and heal within 8 weeks. Rarely develop fulminant hepatitis and death. In this study, we present a case of a 62-year-old woman who had chronic viral hepatitis B and developed toxic hepatitis after receiving ACA treatment. When ACA was discontinued, the patient’s symptomps improved and her liver enzyme levels reduced to near to the normal range.

Keywords: Amoxicillin-clavulanic acid, toxic hepatitis