E-ISSN: 1305-9327 ISSN: 1305-9319
Urine macrophage migration inhibitory factor levels in children with renal scarring due to recurrent urinary tract infections
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Researches
VOLUME: 7 ISSUE: 2
P: 52-55
June 2011

Urine macrophage migration inhibitory factor levels in children with renal scarring due to recurrent urinary tract infections

Med J Bakirkoy 2011;7(2):52-55
DOI: 10.5350/BTDMJB201107202
Asuman Gedikbaşı 1
Sami Hatipoğlu 2
Alev Yılmaz 3
Esra Sevketoglu 2
Savaş Karyağar 4
Aysel Kıyak 3
Mehmet Mulazimoğlu 4
Gönül Aydoğan 3
Tevfik Özpaçacı 4
1. Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi Biyokimya Laboratuvarı, İstanbul
2. Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi Çocuk Sağlığı ve Hastalıkları Kliniği, İstanbul
3. Bakırköy Kadın Doğum ve Çocuk Hastalıkları Hastanesi, Pediatrik Nefroloji Kliniği, İstanbul
4. Okmeydanı Eğitim ve Araştırma Hastanesi, Nükleer Tıp Kliniği, İstanbul
No information available.
No information available
Received Date: 25.03.2011
Accepted Date: 14.04.2011
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ABSTRACT

Conclusion:

In patient with renal scarring, for using urine MIF levels as a biochemical marker, more prospective studies are needed on this subject.

Results:

Urine MIF levels were statistically significantly high in renal scar group than without scar group (p<0.001), the average levels of urine MIF in scar group was 331,14 ± 256,20 (254,85) than those in patients without scar 195,30±298,68 (111,55) MIF/creatinine levels were not statistically significant between groups (p>0.05).

Material and methods:

Eighty eight children with renal scarring due to recurrent urinary tract infection were included. Dimercaptosuccinic acid (DMSA) scintigraphy revealed renal scarring in 44 of them. Macrophage migration inhibitory factor were analyzed by ELISA from the urine samples in both groups.

Objective:

Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine that plays an important role in several disease including sepsis, pneumonia, diabetes, rheumatoid arthritis, inflammatory bowel disease and cancer. In this study, our aim was to examine the levels of macrophage migration inhibitory factor in children with renal scarring due to recurrent urinary tract infection.

Keywords:
Urinary tract infection, renal scarring, macrophage migration inhibitory factor